Commercial Sims are Sims in MySims (Console/PC/Apple Arcade) whose homes will double as a business/municipal building when they reside in town. Their homes have a special layout of a large big room and a medium room. All Commercial Sims, except Buddy, will have tasks for the player to build certain furniture for them. Each Star Level will bring new Commercial Sims, with the exception of Star Level 5. Completing tasks for Commercial Sims will raise the town's Star Level and gain friendships, special blueprints, and decoratives.

Upon becoming a Commercial Sim's best friend, they will reward the player with their outfit, which can be found in the Dresser or Costume Chest. Commercial Sims have special reactions for when a player does a social interaction with them, as well as special actions they do while standing around (such as Vic Vector playing a portable video game, or Elmira Clamp reading a book while standing). Each Commercial Sim will have special house parts, which can be used on future buildings from that point. Up to two Sims can be in a Commercial Sim's home at a time (not including the player and the Sim living there).

The initial Wii version has 20 Commercial Sims. An additional 6 were later added on other platform releases, making a grand total of 26 Commercial Sims overall.

Star Levels

Apart from the starter Commercial Sims, most will not appear until the town reaches a specific Star Level.

Star Level 0

Star Level 0 starts with 3 Commercial Sims:

• Rosalyn P. Marshall, the town mayor.
• Poppy, who runs a flower shop.
• Buddy the Bellhop, who runs the town hotel.

Star Level 1

Star Level 1 will bring 3 new Commercial Sims:

• Chef Gino Delicioso, who runs an Italian restaurant.
• DJ Candy Supergroove, who runs a night club.
• Sir Vincent Skullfinder, museum curator.

Star Level 2

Star Level 2 will bring 4 new Commercial Sims:

• Elmira Clamp, who runs a library.
• Ms. Nicole Vogue, who runs a boutique.
• Roxie Road, who runs an ice cream shop.
• Vic Vector, who runs an arcade.

Star Level 3

Star Level 3 will bring 8 new Commercial Sims (5 on Wii):

• Master Aran, who runs a martial arts school.
• Goth Boy, who runs a haunted house.
• Dolly Dearheart, who runs a costume shop.
• Shirley, who runs a beauty salon.
• Chef Watanabe, who runs a sushi restaurant.

Exclusive

• Natalia Roshmanov, who runs a secret headquarters.
• Tad "Flipper" McCaffrey, who runs a pool house.
• Wendalyn, who runs a potion shop.

Star Level 4

Star Level 4 will bring the last 8 new Commercial Sims (5 on Wii):

• Dr. F, who runs a mad science lab.
• Trevor Verily, who runs a theater.
• Professor Nova, who runs an observatory.
• Madame Zoe, who runs a fortune teller's.
• Cap'n Ginny, who runs a pirate themed tavern.

Exclusive

• Alexa Lexington, who runs a robot lab.
• Cedella, who runs a café.
• Terry Toymender, who runs a toy store.

Trivia

• If the player gives a Commercial Sim an item to become their best friend and later removes it, they cannot become best friends again unless the player puts it back, even if they have replaced it with other items.
• Although Shirley and Master Aran are accessible at Star Level 3, their final tasks cannot be completed until reaching Star Level 4.
• Goth Boy and Dr. F are the only Commercial Sims whose entrances to the medium room of their home will be in the middle of the wall in the big room, rather than at the corner.